Nootropics Dihexa Powder CAS from freemexy's blog

Catalogue number: H293745
Chemical name: N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa)
Synonyms: N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide
CAS Number: 1401708-83-5
Structure: Nootropics Dihexa Withcas: 1401708-83-5
Molecular form.: CHNO
Appearance: White Solid
Melting Point: 209°C (dec.)
Mol. Weight: 504.66
Storage: Hygroscopic, Refrigerator, under inert atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)

Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) is an angiotensin IV analog as a procognitive/antidementia agent.
References: McCoy, A., et al.: J. Pharm. Exp. Ther., 344, 141 (2013)
Dihexa powder, also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models ofAlzheimer's disease-like mental impairment. In an assay of neurotrophicactivity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.

According to a patent, "Short duration safety studies with Dihexa have uncovered no apparenttoxicity. Of particular note is a lack of neoplastic induction, since c-Met is recognized as anoncogene. This is unsurprising since oncogenesis requires multiple mutations including both oncogene induction and tumor suppressor attenuation.

Previous post     
     Next post
     Blog home

The Wall

No comments
You need to sign in to comment