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The National Institute for Health and Care Excellence (NICE) has recommended degarelix (marketed as ‘Firmagon’) for a group of men with advanced hormone-dependent prostate cancer – those with spinal metastases.Degarelix powder

This announcement comes after a review process lasting over 3 years, and follows NICE’s most recent draft Appraisal Consultation Document (ACD) published in June 2015, which recommended against the use of degarelix within its marketing authorisation for treating advanced hormone-dependent prostate cancer.

Degarelix was first approved by the European Medicines Agency for men with advanced hormone-dependent prostate cancer in 2009, and has been available in the UK since 2010.

The ongoing changes to NICE’s guidance since then have resulted in great variations in access to degarelix across the UK, and between regions in England and Northern Ireland.

The use of degarelix has been recommended in Scotland and Wales for several years for its full indication.1, 2

“It is great news for patients with advanced hormone-dependent prostate cancer that Firmagon [degarelix] has finally been approved by NICE,” said Professor Roger Kirby, Professor of Urology, University of London, UK.

“As a urologist, I am pleased that this rapidly acting and effective treatment is now available for men whose disease has spread to the spine.”Testosterone-lowering therapy is considered a primary treatment for prostate cancer.3

In clinical studies, degarelix demonstrated an immediate reduction in testosterone levels upon initial use, achieving clinically significant levels within 3 days.4.Maintenance therapy with degarelix led to long-term testosterone suppression for up to 5 years.5
Degarelix has shown significantly longer progression-free survival,6 compared with luteinising hormone-releasing hormone (LHRH) agonists, an existing hormonal therapy.

Furthermore, clinical studies have demonstrated that men treated with have a significantly reduced risk of cardiovascular disease, fewer musculoskeletal events and a lower incidence of urinary tract events than those treated with LHRH agonists.7, 8

Treatment with degarelix has also demonstrated a more rapid reduction in prostate-specific antigen (PSA);4 a significant reduction in the risk of PSA progression,9 compared with existing hormonal therapies; and a better control of serum alkaline phosphatase6 (S-ALP), which is indicative of tumour activity within bones.

Rowena Bartlett, Chief Executive, Tackle Prostate Cancer, commented: “The revised NICE recommendation means that those men living with advanced hormone-dependent prostate cancer now have a significantly better chance of receiving this important therapy. Prostate cancer is still one of the lead killers of men living in the UK, and there is a need for much greater urgency in making treatments available. This decision also comes at a particularly challenging time for prostate cancer treatment in the UK, with access to cancer drugs in England becoming increasingly impacted by cuts to the Cancer Drugs Fund.”

freemexy Sep 20, 09:56AM

99% Lyophilized Hormone Hexarelin Acetate / Hexarelin (2mg/Vial) Polypeptides Powder

Hexarelin powder is a six-amino acid peptide. Studies have shown that hexarelin is actually more effective and longer lasting than g hormone releasing hormone (GHRH). It is also known that GHRP-6 has a synergistic effect with GHRH, causing a far greater release than either of these substances alone. By combining GHRP-6 with Hexarelin, a more potent GH releasing peptide combination is created than ever heard of. The potential clinical usefulness of these GH releasing hexapeptides is also reinforced by observations that long-term administration produces elevations in circulating concentrations. Long term treatment with GHRP-6 similarly has been shown to elevate as well as -binding protein-3 concentrations and promote linear growth.

Hexarelin comes in a freeze dried powder just like the other GHRP peptides and storage should be done in a cool dry place until reconstituted and placed in a refrigerator. Bacteriostatic water is used to reconstitute the powder and an insulin syringe is the preferred method for administering subcutaneous injections of hexarelin. Users will notice 200mcgs is the saturation dose for hexarelin and over a few weeks of use total desensitization may begin to take place. Also, the occasional flare up of the pituitary has been noted when dosing far beyond saturation doses. Desensitization can be cleared easily by taking a break from hexerlin usage for a few days to a few weeks. This GHRP is the strongest, and because of the desensitization factor, I believe the optimal way to use this peptide would be to blend it at low doses with other GHRP’s like GHRP6 or iPamorelin.
Hexarelin (HEX) is a peptide GH secretagogue, structurally similar to GHRP-6, in the factor family which stimulates the release of g hormone (GH). It can be used medically to treat GH deficiency. Hexarelin is becoming a popular choice as a performance enhancement drug. Due to Hexarelin’s ability to increase secretion of natural Hormone, most of its effects are similar to those of synthetic GH, although to a slightly lesser extent. Effects of its use include: increase in strength, growth of new muscle fibers, increase in the size of already existing muscle fibers, neural protection, joint rejuvenation, protection and healing. Also, the GH receptors in adipose (fat) tissue allow for potential fat reduction with Hexarelin use. The increase of circulating GH through Hexarelin use causes levels to rise in the liver. is the prime cause of muscle growth in response to GH stimulation.

Hexarelin is comprised of a chain of amino acids that when administered stimulates the pituitary in a pulsating fashion causing it to release more GH into the body. Unfortunately, at this time it is not fully understood how Hexarelin causes such a strong increase in GH compared to say GHRP-6; data merely shows that the increase is significantly more.

The use of Hexarelin has also been shown to increase prolactin and cortisol levels in the body, far more so than other GH products. Prolactin increases should not be as strong as they may be with certain steroids, but they may be significant in some cases. Hexarelin will not increase Ghrelin levels in the body like GHRP-6 despite being very similar on a structural basis.

Data has also shown Hexarelin to be one of the faster acting GH products on the market but also one of the few that stops working after a set amount of time. GH levels should increase quickly and in a beneficial manner in as little as four weeks. However, use past the sixteen week mark has been shown to produce little to no results. Use of any worth will normally fall in the 8-12 week range with 4-6 weeks of no use (minimum) between Hexarelin cycles. The peptide will not render pituitary function (GH production) post use as will steroids in regards to the testicles, but it does appear to have a short lived actionable period of use.

freemexy Sep 20, 09:46AM

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shorifshopnil Sep 20, 09:46AM

Bremelanotide
Alias: Bremelanotide,α-MSH powder, PT-141 powder, PT 141 Powder,Brmelanotice,Bremelanotide
CAS Registry Number: 189691-06-3
MF: C50H69N15O10
MW: 1040.17736
Appearance: White powder
Water Content(Karl Fischer): ≤ 5.0%
Acetate Content(by HPLC): ≤ 15.0%
Amino Acid Composition: ± 10% of theoretical
Purity(by HPLC): ≥ 97.0%
Single Impurity(by HPLC): ≤ 1.0%
Peptide Content(by %N): ≥ 80%
Assay(By Anhydrous, Acetic Acid-free): 95.0~105.0%
Bacterial Endotoxins: ≤ 5EU/mg
Grade: Pharmceutical Grade
Storage: Shading, confined preservation
Usage: Bremelanotide is a compound under drug as a treatment for female and male sexual dysfunction, hemorrhagic shock and reperfusion injury.

Product Description :

Bremelanotide or PT-141 is the generic term for a new research peptide for use in helping improve sexual dysfunction in men (erectile dysfunction or impotence) as well as helping improve sexual dysfunction in women (sexual arousal disorder).
Bremelanotide, PT-141 does not act on the vascular system like the former compounds but it is known and has been shown to help increase sexual activity in both male and female mammals. Bremelanotide PT-141 allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation.

freemexy Sep 20, 09:38AM

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shorifshopnil Sep 20, 09:32AM

Raw Bremelanotide,Bremelanotide,α-MSH powder, PT-141 powder, PT 141 Powder is a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system. It development by Palatin Technologies as a treatment for female sexual dysfunction.

Bremelanotide,α-MSH (PT-141) powder has been used in trials studying the treatment of Sexual Arousal Disorder, Female Sexual Arousal Disorder, and Hypoactive Sexual Desire Disorder.
Product Name Raw Bremelanotide,α-MSH (PT-141) powder
Chemical Name PT141 Acetate,BreMelanotide Acetate;
Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys);BREMELANOTIDE;Brmelanotice;Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH;Bremelanotide, PT141,

PT-141;BREMELANOTIDE PT141;N-Acetyl-L-

norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysine (2-7)-lactam
Sequence Ac-Nle-cyclo(Asp-His-DPhe-Arg-Trp-Lys)
Brand Name Rekynda (tentative)
Drug Class Peptides
CAS Number 189691-06-3
InChIKey FFHBJDQSGDNCIV-MFVUMRCOSA-N
Molecular Formula C50H68N14O10
Molecular Weight 1025.182
Monoisotopic Mass 1024.524284446
Melting Point N/A
Biological Half-Life 120 minutes
Color N/A
Solubility Soluble in DMSO
Storage Temperature 0 – 4 C for short term (days to weeks), or -20 C for long term (months).
Application used in trials studying the treatment of Sexual Arousal Disorder, Female Sexual Arousal Disorder, and Hypoactive Sexual Desire Disorder.

freemexy Sep 20, 09:29AM

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shorifshopnil Sep 20, 09:26AM

High Quality Ganirelix Acetate for Lab Supply with GMP

Product name:Ganirelix powder
CAS:129311-55-3
MF:C80H113ClN18O13
Purity:.98%min
Storage:Dry Cool Place
Grade:Medicine Grad
Specification:5mg/vial or 10 mg/vial
Supply Ability:1000 kits per Month
Packing:10vials per kits
Color:White
Appearance:White powder
Suitable for:Adult
State:Solid
Form:Powder
Type:API

Raw Ganirelix Acetate powder is the acetate salt form of ganirelix, a synthetic decapeptide with high antagonistic activity against naturally occurring gonadotropin-releasing hormone (GnRH). Ganirelix directly competes with the GnRH for receptor binding in the anterior pituitary gland, thus induces a rapid and reversible suppression of the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH). This agent is used for the inhibition of premature LH surges in women undergoing controlled ovarian hyperstimulation, and in combination with other hormones for retrieval of the mature follicles for in-vitro fertilization.

freemexy Sep 20, 09:18AM

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shorifshopnil Sep 20, 09:17AM

High Purity Pregabalin Powder CAS 148553-50-8 Reliable Supplier

Pregabalin powder supplier is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults.It has also been found effective for generalized anxiety disorder and is (as of 2007) approved for this use in the European Union.It was designed as a more potent successor to gabapentin.
1) Pregabalin Powder is a novel γ-aminobutyric acid (GABA) receptor agonist, can block the voltage-dependent calcium channels to reduce neurotransmitter release.

2) The main clinical for the treatment of peripheral neuropathic pain as well as part of adjuvant treatment of focal seizures.

3) Treatment of epilepsy in developing the most promising drug in a drug treatment better and more convenient administration. Can also be used to treat pain and anxiety.

Applications:

1)Pregabalin, is a new type of GABA receptor agonists, can block the voltage dependence calcium channel to reduce the neurotransmitter release.

2)Pregabalin mainly used for clinical treatment of peripheral neuropathy and auxiliary for the treatment of localized part seizures.

freemexy Sep 20, 09:07AM
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